Enhanced Tau Phosphorylation in the Hippocampus of Mice Treated with 3,4-Methylenedioxymethamphetamine ("Ecstasy")
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چکیده
منابع مشابه
P-34: Crocin Ameliorate The In Vitro Fertilization (IVF) in Mice Treated with Cyclophosphamide
Background Oxidative stress induced by cyclophosphamide (CP), as a chemotherapeutic agent, causes vulnerability of sperm and declining the fertility capacity. Then in this study the effect of crocin (saffron extract) on amelioration of these side effects was investigated. MaterialsAndMethods In this study 24 mice were divided in three groups (n=8). Control group received normal saline (0.2 ml/d...
متن کاملEcstasy: 3,4-methylenedioxymethamphetamine (MDMA).
The crystal structure of 3,4-methylenedioxymethamphetamine [systematic name: N-methyl-1-[3,4-(methylenedioxy) phenyl]-2-aminopropane] hydrochloride, C11H15NO2.HCl, also known as 'ecstasy' or MDMA, has been determined by X-ray diffraction.
متن کاملTau phosphorylation in hippocampus results in toxic gain-of-function.
The MAP (microtubule-associated protein) tau binds to tubulin, the main component of MTs (microtubules), which results in the stabilization of MT polymers. Tau binds to the C-terminal of tubulin, like other MAPs (including motor proteins such as kinesin) and it therefore may compete with these proteins for the same binding site in the tubulin molecule. In pathological conditions, tau is the mai...
متن کاملMethylenedioxymethamphetamine (MDMA, ‘Ecstasy’): Neurodegeneration versus Neuromodulation
The amphetamine analogue 3,4-methylenedioxymethamphetamine (MDMA, ‘ecstasy’) is widely abused as a recreational drug due to its unique psychological effects. Of interest, MDMA causes long-lasting deficits in neurochemical and histological markers of the serotonergic neurons in the brain of different animal species. Such deficits include the decline in the activity of tryptophan hydroxylase in p...
متن کاملThe Effects of 3,4-methylenedioxymethamphetamine on Neurogenesis in the Hippocampus of Male Rats
Introduction: The administration of 3,4-methylenedioxymethamphetamine (MDMA) or ecstasy causes memory impairment, whereas neurogenesis improves memory and learning. Hence, this study evaluated the effects of MDMA on neurogenesis in the hippocampus of male rats. Methods: Adult male Wistar rats received intraperitoneal (IP) injections of MDMA (10 mg/kg). We assessed nestin, sex-determining regio...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2008
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.0159-08.2008